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The recent experience of Covid, and millions of long Covid sufferers, has raised awareness of the growing problem of “brain waste” — dead cells in the brain that lead to neuroinflammation and neurodegeneration. This is brought about by the buildup of ‘cellular waste’, that the body’s glymphatic system fails to remove. Which can leave people disabled, with conditions such as Alzheimer’s and Perkinson’s.

With its unique ability (to stimulate TRPV1 receptors) in the sinus region, capsaicin can activate sensory nerves that trigger pathways to enhance cerebral lymphatic drainage. A 2025 study found that stimulating TRPV1 receptors in the face/neck (by capsaicin) enhances CSF (Cerebrospinal Fluid) flow and boosts the glymphatic system, which removes metabolic waste from the brain.” AI

In addition to promoting the removal of dead cells (brain waste), capsaicin can also help with synaptogenesis, generating new synapses, especially after brain injury.